Decoding Kratom Metabolism: An Insight into its 40+ Alkaloids [Health Advisory]

Ever wondered about the inner workings of kratom? How does this tropical plant, often used in traditional medicine, interact with your body’s complex metabolic system? Well, you’re not alone. It’s a topic that’s piqued the curiosity of many, and it’s time we delve into it.

Key Takeaways

  • Kratom, or Mitragyna speciosa, is a tropical tree from Southeast Asia known for its high alkaloid content, with Mitragynine and 7-Hydroxymitragynine being the primary compounds.
  • This plant has been traditionally used for pain relief, fighting fatigue, and mood enhancement, over the years, its use as a dietary supplement in Western markets has surged.
  • Kratom’s alkaloids interact with the body’s opioid receptors creating their observed effects, however, this plant isn’t like traditional opioids due to its unique biochemical composition.
  • Kratom’s active compounds, Mitragynine and 7-Hydroxymitragynine are primarily metabolized in the liver, transforming into several metabolites. The process involved Phase I and Phase II metabolism, each mediated by specific enzymes.
  • Factors like user genetics, diet, and concurrent medication can influence the metabolism of kratom, thus affecting the individual’s experience.
  • While Kratom has potential benefits including improved mood, pain relief, and assistance with opioid withdrawal, it’s vital to be wary of possible side effects, such as constipation, dependency, withdrawal, and liver toxicity.

Understanding Kratom and Its Uses

Kratom grabs attention with its biochemical complexity and potential benefits. But before diving into kratom’s metabolic story, let’s set the stage.

Overview of Kratom

Originated from Southeast Asia, Kratom, scientifically known as Mitragyna speciosa, is a tropical tree. It’s renowned for its alkaloid content, with two compounds standing out from the crowd: Mitragynine and 7-Hydroxymitragynine. These alkaloids interact with the body’s opioid receptors, engendering a range of responses. However, kratom’s unparalleled biochemical composition sets it apart from typical opioids, earning it both spotlight and controversy.

Common Uses in Traditional and Modern Medicine

Historically, kratom leaves have left their fingerprints on traditional medicine practices. Here’s a concise breakdown of prevalent uses:

  1. Pain Relief: The alkaloids present in kratom leaves act on the body’s pain pathways, mimicking opioids without causing dependence.
  2. Fighting Fatigue: Laborers in Southeast Asia used kratom to combat fatigue and boost their energy levels, enhancing productivity.
  3. Mood Enhancement: Through its psychoactive properties, kratom has found use in mood enhancement, relieving symptoms of anxiety and depression.

Fast forward to the present, and you’ll find a rise in kratom use as a dietary supplement. Despite the FDA’s warnings, its demand in Western markets is surging. Aided by the internet, users exchange tips about kratom dosing, strains, and efficacy for various conditions. While scientific research is catching up, anecdotal evidence sings praises of kratom’s therapeutic capabilities.

Indeed, understanding the metabolism of kratom presents a challenge, but it’s crucial. As kratom steps out of the shadows, solid data paves the way. Stay tuned for more in-depth coverage on how kratom interacts with the body’s metabolic system. In the meantime, browse a high-quality range of kratom at PureCBDNow, including the potent alkaloid 7-Hydroxymitragynine.

The Chemical Composition of Kratom

Within kratom’s lush leaves resides a cocktail of phytochemicals. The powerhouse duo, Mitragynine and 7-Hydroxymitragynine, dominate this composition, providing the plant’s acclaimed benefits.

Key Alkaloids in Kratom

A mound of more than 40 different alkaloids lay within kratom. Mitragynine grasps the highest percentage, making up about 66% of the total alkaloid composition. Take the reins on the lower end, another star player: 7-Hydroxymitragynine. It may grab a slimmer fraction of the total alkaloids but its potency surpasses Mitragynine.

Here’s an up-close look at the alkaloid arena in a kratom leaf, measured as a percentage of total alkaloid composition:

Alkaloid Percentage
Mitragynine 66%
Paynantheine 9%
Speciogynine 7%
7-Hydroxymitragynine ~2%

[Source: Comprehensive Drug Testing, Inc.]

Effects of Alkaloids on the Human Body

These alkaloids aren’t just riding along for the journey— they’re driving the effects. Mitragynine and 7-Hydroxymitragynine interact with opioid receptors in the human brain. Don’t mistake these interactions as similar to traditional opioid drugs: they’re distinct. The directions they lead are unique pathways of mood enhancement, fatigue relief, and pain management.

Your journey with kratom doesn’t end here, it merely starts. The next stop: Metabolism of this plant and the potential health implications it carries.

The Metabolism of Kratom

Delving further into kratom’s bioactivity, we tap into the curious world of its metabolism. Including the breakdown of its chief alkaloids, this process underlines why kratom impacts users in the noticeably varied ways it does.

How Kratom Is Metabolized in the Human Body

Primarily occurring in the liver, the human body metabolize kratom’s active compounds, Mitragynine and 7-Hydroxymitragynine^1^, spurring numerous byproducts. Imagine this as a factory line. As these compounds go through the liver’s enzymatic process, they’re transformed into several metabolites, each assuming a unique biological function.

  1. Phase I Metabolism: Mitragynine is metabolized mainly by cytochrome P450 (CYP) enzymes such as CYP3A4, CYP2D6, and CYP2C9[^2^].
  2. Phase II Metabolism: Through the process of glucuronidation and sulfation, metabolites then undergo conjugation, further modifying their chemical structure[^3^].

For illustrative understanding, consult the table below.

Phase Enzymes Involved Resulting Metabolites
Phase I CYP3A4, CYP2D6, CYP2C9 Multiple
Phase II Glucuronidation, sulfation Conjugated metabolites

[^2^]: Olsen, L., Holzknecht, B., Hansen, S., & Frølund, B. (2019). Kratom alkaloids: The structure, pharmacokinetics, and pharmacological properties. Drugs R D, 19(3), 201-211. doi:10.1007/s40268-019-00281-
[^3^]: Hassan, Z., Muzaimi, M., Navaratnam, V., Yusoff, N. H., Suhaimi, F. W., Vadivelu, R., … & Müller, C. P. (2013). From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction. Neuroscience & Biobehavioral Reviews, 37(2), 138-151.

Factors Influencing Kratom Metabolism

Several factors affect the rate and effect of kratom metabolism. User genetics, diet, and concurrent medication usage play substantial parts in shaping one’s experience. Also, the presence of food in the stomach impacts absorption rates[^4^].

  1. Genetics: Genetic polymorphisms can influence CYP metabolic activity, which in turn affects how quickly kratom is metabol

Health Implications of Kratom Consumption

Kratom’s health implications vary, with both potential benefits and possible side effects.

Potential Benefits

Kratom, specifically its alkaloids Mitragynine and 7-Hydroxymitragynine, can exert its effects by interacting with the body’s opioid receptors. Here, they may:

  • Improve mood: Studies illustrate Kratom’s potential to enhance mood. Further, consuming this plant might lead to increased energy and alertness.
  • Provide pain relief: Research shows that Mitragynine and 7-Hydroxymitragynine are significant contributors to pain relief. They provide an analgesic effect comparable to opioids, sans the major drawbacks.
  • Assist with opioid withdrawal: Several anecdotal reports allude to Kratom’s efficacy in managing opioid withdrawal symptoms. However, more scientific research is necessary to confirm these claims.

Possible Side Effects

But it’s not all rosy. Various adverse effects may result from Kratom use. Such include:

  • Constipation: Chronic usage might lead to bowel impairment, a side effect typical with opioid use.
  • Dependency and withdrawal: Regular consumption may lead to a dependence on the plant, which might trigger withdrawal symptoms upon cessation.
  • Liver toxicity: There’s a handful of cases reporting hepatotoxicity due to prolonged use. This calls for more in-depth research into Kratom’s long-term effects.

While the health implications seem apparent, it’s necessary to consider individual factors like genetics, diet, or medication usage, as they could influence your body’s metabolism of Kratom. Always consult a health professional before incorporating new supplements like Kratom into your routine.

To explore a more extensive range of Kratom and its various extracts, check out Pure CBD and their 7-Hydroxymitragynine offerings. With the right knowledge and safe practices, you can harness Kratom’s potential benefits while safeguarding against its possible risks.


Understanding kratom’s metabolism is key to harnessing its potential benefits and mitigating risks. Remember, it’s the liver that processes kratom’s alkaloids, with individual factors such as genetics, diet, and medication usage playing crucial roles. The mood-enhancing and pain-relieving properties of kratom can be beneficial, but it’s also important to be aware of possible side effects. It’s not a one-size-fits-all solution. As with any substance, the effects can vary from person to person. Always consult a health professional before incorporating kratom into your routine. This ensures you’re making an informed decision, taking into account your unique body chemistry and overall health. Knowledge is power, and understanding the metabolism of kratom empowers you to make the best choices for your wellbeing.

Leave a Comment

Item added to cart.
0 items - $0.00